TOPOLOGY :: Measuring the
Topology, Ecology, and Travel Strategies
of Cancer Cells over the Course
of Disease
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:: Project Overview
"Topology" project is focused at investigating the aforementioned challenges
at the level of structural properties and grouping behaviors of cancer cells
with other cells in their microenvironment, by taking a comprehensive sampling
across the time and space heterogeneity of the tumor via solid and fluid
biopsies.
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We will investigate the physical properties and morphologic characteristics
of specific populations of tumor cells in various phases and spatial regions of
the disease and characterize the grouping behaviors they exhibit in their unique
blood microenvironment. Identifying similarities and differences among the
various tumor cells populations will identify meaningful heterogeneity and thus
lend insight into which tumor cells are important.
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