DYNOMICS :: The Genomics and
Transcriptomics of Cancer Cells
over the Course of the Disease
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:: Project Overview
The Dynomics Project is designed to provide digital -omic analysis of cancer
that will serve as a platform for assessing physical heterogeneity across time
and space.
Our goal is to generate informative features of the genome and its
transcripts that will be integrated with physical measurements to further evolve
the underlying mathematical model.
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"Dynomics" project will:
- genetically and transcriptomically characterize cancer cells in various
geographic regions in the solid and fluid phase of two types of cancer (lung and
colon) at presentation and over the course of the disease;
- genetically and transcriptomically characterize epithelial tumor cell
populations in the peripheral blood of newly diagnosed cancer patients across
differing stages at initial presentation, with evaluation at diagnosis and six
months later.
Toward that goal, we will utilize next generation technologies for DNA
sequencing, to provide a digital readout that can be integrated together with
physical measurements in order to provide a context for the physical
measurements and inform the relationships of physical parameters and cancer
phenotypes. These variables can be further addressed in mathematical simulation
and statistical correlation across the data from all three research projects.
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